Therapeutic Evaluation of Methotrexate with or without Cox-2 Inhibitor in the Management of Canine Mammary Tumours
نویسندگان
چکیده
Spontaneously occurred canine mammary tumours (55) were treated with chemotherapy (Methotrexate), combination chemotherapy with COX-2 inhibitor (Meloxicam) and by surgical therapy. In chemotherapy groups Hb and TEC values reduced significantly (P<0.05) from the base line value at 3rd week of therapy. Histologically, benign and malignant mixed mammary tumours were predominant. Methotrexate and COX-2 inhibitor drug were found effective in the treatment of canine mammary tumours and also they induced more percentage of apoptosis of spontaneous canine mammary tumours. Cox-2 inhibitor (Meloxicam) proved as a good adjunct in the treatment of canine mammary tumours.
منابع مشابه
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